• Hyaline Membrane Disease
• Bronchopulmonary Dysplasia
• Transient Tachypnea of the Newborn
• Meconium Aspiration Syndrome
• Neonatal Pneumonia

• Originates from insufficient surfactant production
• Inadequate surfactant production leads to high air-water (blood) surface
tensions which favour alveolar collapse and gas exchange failure in the lung

•Instability of terminal airspaces due to elevated surface forces at liquid-gas interfaces

•Stable alveolar volume depends on a balance between:

1)surface tension at the liquid-gas interface, and
2) recoil of tissue elasticity

• Collapsed alveoli contain fluid with a high protein content, hyaline
membranes, and lamellar bodies derived from the surfactant layer of lung

http://microanatomy.net/digestive/Lecture_33_Dev_GI_Resp_Kielian_4_slides_per_page.pdf

• Typically, diffuse “ground-glass” or finely granular appearance
• Bilateral and symmetrical distribution
• Air bronchograms are common
• Especially extending peripherally
• Hypoaeration in non-ventilated lungs
• Hyperinflation excludes HMD
• “Granularity” is the interplay of
• Air-distended bronchioles & ducts
• Background of atelectasis of alveoli
• May change from film-to-film if there is
• Expiration (air disappears)
• Better aeration (small bubble formation)

http://www.learningradiology.com/archives2008/COW%20292-TTN/ttnccorrect.htm

•Surfactant consists of phospholipids and protein. It begins to be produced at about 24-28 weeks of pregnancy. Surfactant is found in amniotic fluid between 28 and 32 weeks. By about 35 weeks gestation, most babies have adequate amounts of surfactant.

•Surfactant is normally released into the lung tissues where it helps lower surface tension in the airways. This helps keep the lung alveoli open. When there is not enough surfactant, the alveoli collapse. As the alveoli collapse, damaged cells collect in the airways, creating a “hyaline membrane.”

chest x-rays of lungs - often show a unique "ground glass" appearance called a reticulogranular pattern.

Moderately severe HMD/RDS	Typical appearance of HMD/RDS

• May be impossible to distinguish early stages of BPD from later stages of HMD
• Coarse, irregular, rope-like, linear densities
• Represents atelectasis or fibrosis
• Lucent, cyst-like foci
• Hyperexpanded areas of air-trapping
• Hyperaeration of the lungs
• Conglomerate disease in BPD
• Shifting atelectasis
• Episodes of aspiration or pulmonary edema
• Superimposed pneumonia
• Changes of BPD will revert to normal on the chest radiograph in most patients after the age of two

http://www.learningradiology.com/archives2008/COW%20292-TTN/ttnccorrect.html

Source: Roderick MacPherson M.D. Professor Emeritus Radiology, Medical University of South Carolina

	Mild and self-limited Delayed resorption of fetal lung fluid Hyperinflation of the lungs Fluid in the fissures Laminar effusions Fuzzy vessels http://www.learningradiology.com/archives2008/COW%20292-TTN/ttnccorrect.html •It is thought that slow absorption of the fluid in the fetal lungs causes TTN. This fluid makes taking in oxygen harder and the baby breathes faster to compensate. •rapid breathing rate (over 60 breaths/minute) •grunting sounds with breathing •flaring of the nostrils •retractions (pulling in at the ribs with breathing)
http://www.learningradiology.com/archives2008/COW%20292-TTN/caseoftheweek292page.html

Diffuse “ropey” densities (similar to BPD) irregular infiltrates –Fluffy non-homogeneous infiltrates Patchy areas of atelectasis and emphysema from air-trapping Hyperinflation of lungs Spontaneous pneumothorax and pneumomediastinum Occurs in 25%; usually requiring no therapy Small pleural effusions (20%) No air bronchograms Clearing usually quick if mostly water; days-weeks if mostly meconium http://www.learningradiology.com/archives2008/COW%20292-TTN/ttnccorrect.html

Bilateral patchy coarse infiltrates with hyperinflation Radiologically the typical progression is from global atelectasis in early X-rays to a widespread patchy opacification accompanied by areas of hyperinflation and/or atelectasis. lCauses plugging of the airways with consequent atelectasis lMeconium is irritating to the airways causing a chemical pneumonitis and secondary bacterial infection

http://www.learningradiology.com/archives2008/COW%20292-TTN/ttnccorrect.html

• Perihilar streaky pattern may resemble TTN
• Patchy airspace disease
• Diffuse, relatively homogeneous infiltrates resembling ground-glass pattern of HMD
• Occasionally pleural effusion may occur
• Lobar consolidation from infection is unusual in a newborn
• Group B Strep looks most like HMD
• Term infant with findings of “HMD” should be considered to have pneumonia until proven otherwise

http://www.learningradiology.com/archives2008/COW%20292-TTN/ttnccorrect.html

Spontaneous right pneumothorax (? tension) in newborn. visible lung edge (top arrow) deep sulcus sign silhouette sign right hemidiaphragm mediastinal shift

Subcutaneous emphysema (top arrow) Pneumomediastinum (middle arrow) Pneumoperitoneum Continuous diaphragm sign Rigler's sign (bottom arrow) drain in pericardial space ? thickened bowel wall thermometer in right axilla

This baby has pneumomediastinum.	The dotted line in the upper right lung is the thyroid which is displaced by the pneumomediastinum. The other dotted lines outline the airfilled mediastinum

This baby has a right upper lobe consolidation with some associated collapse

This baby has multiple bifid/conjoined ribs. ? thoracic vertebral anomalies

Baby with bowel and stomach in herniated into left hemithorax. Pneumomediastinum and right pneumothorax •developmental abnormality of the diaphragm resulting in a defect that permits abdominal viscera to enter the chest •1 in 3,000 live births •Males > females •Mortality approaches 50%

This premature baby has a pneumatocoele in the right lung (arrowed). A pneumatocoele is a thinwalled, air-filled, circumscribed collection of abnormal gas. In a neonate the mechanism is likely to be a check-valve type localised increase in airway pressure causing airtrapping. Pneumatocoeles can increase rapidly in size (doubling in size in 24 hours) or may resolve spontaneously.